The September 12, 2008 Edition of Smackdown is a Professional wrestling television show of the WWE's Smackdown brand, it was taped on September 9, 2008 at the Bradley Center in Milwaukee, Wisconsin.
- Michelle McCool, Maria & Brie Bella defeated Maryse, Natalya & Victoria (4:30)
- R-Truth defeated Chavo Guerrero (w/ Bam Neely) (3:45)
- Festus (w/ Jesse) vs. Kenny Dykstra ended in a no contest
- Vladimir Kozlov defeated Funaki & Scotty Goldman in a Two On One Handicap Match (1:20)
- Carlito & Primo defeated Curt Hawkins & Zack Ryder (6:45)
- Jeff Hardy defeated The Brian Kendrick (w/ Ezekiel Jackson) and Montel Vontavious Porter and Shelton Benjamin in a WWE Heavyweight Title #1 Contendership Fatal Four Way Match (15:30)