The May 16, 2008 Edition of Smackdown is a Professional wrestling television show of the WWE's Smackdown brand, it was taped on May 13, 2008 at the Van Andel Arena in Grand Rapids, Michigan.
- CM Punk defeated Chuck Palumbo (5:40)
- Michelle McCool defeated Layla (2:07)
- Finlay & The Big Show (w/ Hornswoggle) defeated Mark Henry & Montel Vontavious Porter (9:53)
- Vladimir Kozlov defeated Funaki (2:30)
- Cherry defeated Maryse (w/ Deuce & Domino) (2:16)
- Matt Hardy defeated Shelton Benjamin (6:31)
- Curt Hawkins, Edge, Vickie Guerrero & Zack Ryder vs. The Undertaker in a Four On One Handicap Match ended in a No Contest