Meredith and George are experiencing morning-after tension at home and at work and it has the rest of the doctors wondering what's up. Derek and Addison are experiencing their own version of morning-after tension as a result of Mark's visit to Seattle. Bailey, returning the favor that was done for her during the Code Black situation, must treat Addison for a specific feminine problem. Izzie and Alex are making headway in their relationship until Denny Duquette comes back. Soon Alex is not-so-oddly jealous of the attention Izzie is showing to Denny. Someone finds comfort in confiding in a patient who is going through an ordeal of his own. Burke deals with a patient and gets to observe the patient's unstable relationship with his fiancée.
Casts:
Chandra Wilson, James Pickens Jr., Kevin McKidd, Caterina Scorsone, Camilla Luddington, Kim Raver, Chris Carmack, Jake Borelli, Anthony Hill, Adelaide Kane, Alexis Floyd, Niko Terho, Midori Francis, Harry Shum Jr.